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Home > About Argatroban > Mechanism of Action
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Argatroban is a direct thrombin inhibitor that reversibly binds to the thrombin active site. |
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Argatroban does not require the cofactor antithrombin III for antithrombotic activity. |
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Argatroban exerts its anticoagulant effects by inhibiting thrombin-catalyzed or thrombin-induced reactions, including fibrin formation and activation of coagulation factors V, VIII, and XIII (see Figure 1). |
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Argatroban also inhibits the effect of thrombin on protein C activation and platelet aggregation.[2] |
Figure 1. Argatroban Inhibits Thrombin-Catalyzed or
Thrombin-Induced Reaction in Coagulation[2,7]
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