Catastrophic heparin-induced thrombocytopenia/thrombosis
syndrome
related to the use of a Port-A-Cath in a breast cancer patient receiving
chemotherapy.
Dai M, Hsieh A, Chao T. Support Care Cancer (2004) 12:537-539.
The Argatroban.com Web site contains links to third-party Web sites on the Internet. These links are provided as a service to individuals interested in more information in HIT. These sites are not part of this GlaxoSmithKline (GSK) Web site. The content and materials in these third-party Web sites are not produced or endorsed by GSK and may refer to uses of our products that are not recommended by GSK.
As with all anticoagulants, bleeding is a serious concern. Argatroban is contraindicated in patients with overt major bleeding or those with hypersensitivity to the product or any of its components. Argatroban should be used with extreme caution in disease states or other circumstances in which there is an increased risk of hemorrhage. Overall major bleeding was reported in 5.3% of Argatroban-treated patients with HIT versus 6.7% of the historical controls. Overall major bleeding was reported in 1.8% of Argatroban-treated patients undergoing PCI versus 3.1% of the historical controls. Intracranial bleeding was not observed in the 568 patients treated with Argatroban for HIT (with or without thrombosis) or in the 91 patients who underwent PCI. The most common nonhemorrhagic side effects in HIT patients, regardless of the relationship to treatment, were dyspnea, hypotension, and fever. In patients undergoing PCI, the nonhemorrhagic side effects, regardless of the relationship to treatment, included chest pain, hypotension, and back pain. Please see full Prescribing Information for additional safety information on Argatroban.
