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Patient Education Materials
 

If You Have Been Diagnosed With Heparin-Induced Thrombocytopenia (ARG169) If You Have Been Diagnosed With Heparin-Induced Thrombocytopenia (ARG169)
Questions and answers about heparin and HIT if you or someone you care about are considering surgery.
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If You Have Been Diagnosed With Heparin-Induced Thrombocytopenia - Spanish (ARG177) If You Have Been Diagnosed With Heparin-Induced Thrombocytopenia - Spanish (ARG177)
Common patient questions and answers on HIT.
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Physician Clinical and Resource Materials

Delayed-Onset of Heparin-Induced Thrombocytopenia and Thrombosis (ARG171)
Delayed-Onset of Heparin-Induced Thrombocytopenia and Thrombosis (ARG171)
Warkentin, TE and Kelton, JG. Ann Intern Med. 2001;135:502-506.
Author describes a syndrome termed delayed-onset heparin-induced thrombocytopenia, in which thrombocytopenia and thrombotic events begin 5 or more days after withdrawal of heparin.
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Argatroban Anticoagulation During Percutaneous Coronary Intervention in Patients With Heparin-Induced Thrombocytopenia (ARG058) Argatroban Anticoagulation During Percutaneous Coronary Intervention in Patients With Heparin-Induced Thrombocytopenia (ARG058)
Lewis et al. Catheterization and Cardiovascular Interventions57:177–184 (2002).
Heparin-induced thrombocytopenia (HIT) is an immune-mediated syndrome associated with thrombosis. Alternative anticoagulation to heparin is needed for HIT patients during percutaneous coronary intervention (PCI). We evaluated argatroban, a direct thrombin inhibitor, for anticoagulation in this setting.
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Argatroban Anticoagulation in Patients with Heparin-Induced Thrombocytopenia (ARG135) Argatroban Anticoagulation in Patients with Heparin-Induced Thrombocytopenia (ARG135)
Lewis, et al. Arch Intern Med. 2003;163:1849-1856.
HIT is an intensely prothrombotic syndrome managed by discontinuation of heparin therapy and treatment with an alternative inhibitor of thrombin. We describe our experience with argatroban, a direct thrombin inhibitor, in patients with HIT or HIT with thrombosis (HITTS).

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HIT Myths and Misconceptions (ARG218) HIT Myths and Misconceptions (ARG218)
Rice L. Arch Intern Med;164:1961-1964.
A discussion of the myths and misconceptions about HIT that “will cause trouble for you and your patients.”
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Argatroban Dosing in Patients with Heparin-Induced Thrombocytopenia (ARG193) Argatroban Dosing in Patients with Heparin-Induced Thrombocytopenia (ARG193)
Verme-Gibboney CN, Hursting MJ. Ann Pharmacother 2003;37:970-5.
Authors evaluated clinical experiences with argatroban dosing, particularly incremental dosage adjustments, during a clinical trial of argatroban anticoagulation in HIT.
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Argatroban Anticoagulant Therapy in Patients With Heparin-Induced Thrombocytopenia (ARG108) Argatroban Anticoagulant Therapy in Patients With Heparin-Induced Thrombocytopenia (ARG108)
Lewis et al. Circulation:103:14;1838-1843.
Heparin-induced thrombocytopenia (HIT) is an immune-mediated syndrome caused by heparin with serious complications. We report a prospective, historical-controlled study evaluating the efficacy and safety of argatroban, a direct thrombin inhibitor, as anticoagulant therapy in patients with HIT or HIT with thrombosis syndrome (HITTS).
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Delayed-Onset of Heparin-Induced Thrombocytopenia (ARG172)
Delayed-Onset of Heparin-Induced Thrombocytopenia (ARG172)
Rice L, et al. Ann Intern Med. 2002;136:210-215.
Author describes several clinical scenarios when the onset or manifestations of heparin-induced thrombocytopenia were delayed.
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Treatment of Heparin-Induced Thrombocytopenia (ARG174) Treatment of Heparin-Induced Thrombocytopenia (ARG174)
Hirsh J, et al. Arch Intern Med. 2004;164:361-369.
This systematic review summarizes the risk for thrombosis in HIT patients when heparin therapy is stopped; evidence of the efficacy of thrombin inhibitors in patients with HIT with and without thrombosis; evidence supporting the use of thrombin inhibitors in patients with a history of HIT who require a coronary intervention procedure; and the risk for bleeding when antithrombotic agents are used.
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Heparin-Induced Thrombocytopenia: One Case at A Time - VHS (ARG228)
Heparin-Induced Thrombocytopenia: One Case at A Time - VHS (ARG228)
In this video, leading clinicians discuss heparin-induced thrombocytopenia through a series of patient case presentations in a variety of hospital settings and utilizing todays most relevant literature and treatment recommendations.

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Heparin-Induced Thrombocytopenia: One Case at A Time - DVD (ARG227)
Heparin-Induced Thrombocytopenia: One Case at A Time - DVD (ARG227)
In this video, leading clinicians discuss heparin-induced thrombocytopenia through a series of patient case presentations in a variety of hospital settings and utilizing todays most relevant literature and treatment recommendations.

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